Custom Peptides
Cayman Chemical EpIfrIedelnol 10mg
A triterpene with anticancer and senescence modifying activities; increases levels of P-gp and MDR2 and enhances doxorubicin-induced cytotoxicity in doxorubicin-resistant K562/ADM cells from 5-20 µM; inhibits doxorubicin-induced senescence in isolated HDFs, as well as replicative senescence in HDFs and HUVECs
Cayman Chemical RhosInhydrochlorIde 10mg
An inhibitor of the Rho-GEF protein-protein interaction; inhibits RhoA activity at 10 and 30 µM; selectively reduces the number and size of MCF-7 breast cancer cell mammospheres over MCF-10A non-cancerous cell mammospheres; inhibits migration and invasion of MCF-7 cells and human mammary epithelial cells expressing RhoC; increases neurite outgrowth in PC12 cells at 30 µM; prevents social defeat stress-induced hyperexcitability and increases spine density in D1-MSNs when administered post-social defeat stress in a mouse model of depression at 40 mg/kg; prevents social defeat stress-induced social avoidance and reductions in sucrose preference in a mouse model of depression
Cayman Chemical 2-HydroxyadIpIc AcId 10mg
A dicarboxylic fatty acid; levels are decreased in tumor tissue from patients with esophageal squamous cell carcinoma; levels are increased in patients with 2-ketoadipic aciduria
Cayman Chemical S-2238hydrochlorIde 10mg
A chromogenic substrate for thrombin; enzymatic cleavage releases pNA which can be quantified by colorimetric detection at 405 nm as a measure of thrombin activity
Cayman Chemical DeoxypodophylotoxIn 10mg
A flavolignan with diverse biological activities; inhibits tubulin polymerization in a cell-free assay at 50 nM; inhibits COX-2 and 5-LO in isolated mouse bone marrow-derived mast cells stimulated with KL, IL-10, and LPS (IC50s = 1.89 and 0.37 µM, respectively); reduces viral yield in the supernatant of HSV-1- or HSV-2-infected MRC-5 cells at 0.02 UG/ml; inhibits aggregation of rabbit platelets induced by PAF, collagen, or arachidonic acid; induces mortality in P. rapae fifth instar larvae (LC50 = 0.02 g/L); reduces tumor growth in a CT26 murine colon cancer model at 70 UG/kg
Cayman Chemical CytarabIn 5-monphosphate 10mg
An active metabolite of cytarabine; is incorporated into DNA by DNA polymerase α, which slows the rate of DNA synthesis by approximately 2000-fold in a cell-free assay; inhibits nuclear and mitochondrial DNA replication in S. cerevisiae at 15 mM; improves survival in an L1210 murine leukemia model at 3.5-75.1 mg/kg
Cayman Chemical F1trIfluoroacetate salt 10mg
An anti-inflammatory peptide; inhibits LPS-induced phosphorylation of IKKα and IKKβ and nuclear translocation of NF-κB (p65) in isolated mouse peritoneal macrophages at 5 µM; decreases serum levels of IL-6, TNF-α, and IL-1β and increases survival in a mouse model of LPS-induced sepsis at 5 mg/kg
Cayman Chemical mthyl AracHDnyl Fluoropho 10mg
An inhibitor of MAGL and FAAH (IC50s = 26.3 and 0.33 nM, respectively); irreversible inhibitor of cPLA2, as well as iPLA2 (IC50 = 500 nM); inhibits A23187-induced arachidonic acid release from human platelets (IC50 = 600 nM)
Cayman Chemical RosIglItazon 10mg
A PPARγ agonist; activates PPARγ1 and PPARγ2 in reporter assays (EC50s = 30 and 100 nM, respectively); selectively activates chimeras containing the LBDs of PPARγ over PPARα and PPARδ in a cell-based reporter assay at 10 mM; an inhibitor of ACSL4 (IC50 = 0.5 µM), inhibits RSL3-induced ferroptosis in Pfa1 cells and Pparg KO cells, and increases survival in a Gpx4 KO mouse model of ferroptosis at 0.0125 mg/ml in the drinking water; decreases HbA1c and fasting blood glucose levels in a rat model of type 2 diabetes induced by STZ and a high-carbohydrate and high-fat diet at 4 mg/kg
Cayman Chemical ZLN005hydrochlorIde 10mg
A small molecule that stimulates the expression of PGC-1α and downstream genes in skeletal muscle cells, improving glucose utilization and fatty acid oxidation at a concentration of 20 μM; 15 mg/kg/day administered to diabetic db/db mice improved glucose tolerance, pyruvate tolerance, and insulin sensitivity
Cayman Chemical TroglItazon 10mg
A selective agonist of PPARγ (EC50s = 0.78 and 0.55 μM for the mouse and human receptors, respectively, in a transactivation assay); selective for PPARγ over PPARα and PPARδ, at which it is inactive at ≤10 μM; exhibits antihyperglycemic and antihyperlipidemic properties in Zucker diabetic fatty rats, reducing plasma glucose and triglyceride levels by 61 and 87% respectively, at 500 mg/kg twice per day; induces cell cycle arrest at the G1 phase in SK-HEP-1 and Hep3B hepatocellular carcinoma cells at 10 μM and increases apoptosis in these cells at ≥30 μM
Cayman Chemical AdrenIc AcId 10mg
A naturally occurring PUFA formed through a 2-carbon chain elongation of arachidonic acid; present in the adrenal glands, brain, testis, and kidney
Cayman Chemical Fulvestrnt 9-sulfon 10mg
An estrogen receptor antagonist and a derivative of fulvestrant; binds to ERα and ERβ and inhibits estrogen-induced gene expression in a reporter assay from 0.1-100 µM
Cayman Chemical Benoxaprofen 10mg
An NSAID; inhibits PGE2 and LTC4 production in A23187-stimulated isolated mouse peritoneal macrophages at 100 µM; inhibits serum-induced chemotaxis of isolated rat peritoneal leukocytes at 25 and 50 UG/ml; induces hemolysis in isolated human erythrocytes and histamine release in isolated rat peritoneal mast cells in a light-dependent manner at 10 µM; reduces carrageenan-induced paw edema and yeast-induced fever in rats and acetic acid-induced writhing in mice